J Clin Anesth 2000;12:2659. A healthcare provider uses a laryngoscope to guide an endotracheal tube (ETT) into the mouth or nose, voicebox, then trachea. Obese patients have a higher incidence of adverse airway events on induction and emergence from anesthesia37. BMC Anesthesiol 2018;18:162. 133. FESS is the most common surgery for sinus conditions. Comparison of, 93. Procedure. Nasal saline irrigation flushes out the nasal and sinus cavities to manage polyps. Highlight selected keywords in the article text. It will also minimize the risk of excessive coughing on emergence from anesthesia and in the immediate postoperative period, which may provoke postoperative bleeding. Bergese SD, Patrick Bender S, McSweeney TD, et al. Predictors of unanticipated admission within 30 days of outpatient sinonasal surgery. Smooth emergence in men undergoing nasal surgery: the effect site concentration of, 138. These injuries . Altered mental status/unconsciousness. Your doctor might want to do it because you're unconscious. Esophageal perforation: life threatening complication of endotracheal Jaw surgery, also known as orthognathic (or-thog-NATH-ik) surgery, corrects irregularities of the jaw bones and realigns the jaws and teeth to improve the way they work. Randomized controlled trial comparing the supraglottic airway to use of an endotracheal tube in sinonasal surgery. Kaplan A, Crosby GJ, Bhattacharyya N. Airway protection and the, 51. Effective administration of supplemental oxygen (O2) during FESS is problematic, and blunting fluctuating levels of noxious stimulation may be difficult due to the highly variable patients responses. Otolaryngol Clin North Am 2016;49:53147. Outpatient FESS can be considered a low-risk surgical procedure, with similar rate of major complications (cerebrospinal fluid leak, meningitis, hemorrhage, orbital injuries) recorded for both primary and revision cases (0.36% vs. 0.46%, odds ratio=1.26; 95% confidence interval: 0.792.00)8. Parida S, Badhe AS. You may be trying to access this site from a secured browser on the server. 158. Thirty years of endoscopic sinus surgery: What have we learned? Intranasal atomised dexmedetomidine optimises surgical field visualization with decreased blood loss during, 113. 104. As with any surgery, there are risks involved with having endoscopic sinus surgery. You do not have to be intubated for all General anesthetic. Although this algorithm could be useful in elective Oro-Maxillo-Facial surgery, we would like to highlight the challenges facing nasotracheal intubation during anaesthesia for patients with recent maxillo-facial injuries. Kelly EA, Gollapudy S, Riess ML, et al. Anesth Analg 2000;90:699705. Minerva Anestesiol 2009;75:25968. When a Ventilator Is Necessary - Verywell Health (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702057/). AWAKE Study Group. Major complications of airway management in the UK. Br J Anaesth 1996;76:6637. Amorocho MC, Fat I. Anesthetic techniques in endoscopic sinus and skull base surgery. Some small randomized trials have shown that compared with IV remifentanil or esmolol, IV dexmedetomidine produced comparable decreases in HR and MAP113,114, but similar to clonidine caused more somnolence and prolonged recovery room stay in the immediate postoperative period115. Kim H, Ha SH, Kim CH, et al. Williams PJ, Thompsett C, Bailey PM. Boezaart AP, Van der Merwe J, Coetzee A. 42. A comprehensive literature review (years 20002019) was performed with a focus on FESS topics related to preoperative patient evaluation and preparation, airway management, and optimization of the major anesthetic and surgical goals. Adv Clin Exp Med 2014;23:6978. Am J Rhinol Allergy 2018;32:36973. Dont take aspirin for at least 10 days before your surgery. Srivastava U, Dupargude AB, Kumar D, et al. Gomez-Rivera F, Cattano D, Ramaswamy U, et al. Quality of surgical field during, 92. The indication for surgery may be purely cosmetic, post trauma, reconstructive after tumor resection or to improve nasal breathing. 88. No effect of adjusting the CO2 levels to either hypocapnia or hypercapnia94, choosing pressure-controlled versus volume-controlled ventilation133, with or without positive end-expiratory pressure (PEEP)132 could be demonstrated, but lowering mean inspiratory pressure below 15cmH2O was found to be beneficial if PEEP was used concomitantly132. One, is the Bailey maneuver134, which involves insertion of the LMA behind the existing ETT at a sufficiently deep plane of anesthesia, removal of the ETT, and administration of the ventilatory support through the LMA until the return of spontaneous ventilation and awakening from anesthesia. Chung F, Memtsoudis SG, Ramachandran SK, et al. In the past sinus operations were done through incisions . 58. Lastly, the postoperative period for patients undergoing FESS is discussed with an emphasis on approaches that facilitate prompt hospital discharge with high patient satisfaction. Can J Plast Surg 2009;17:916. 1 Any surgery that requires intubation , which is when a tube is placed in the mouth and down the airway can also lead to mouth and throat discomfort. Types. This may be a sign of infection. 30. How Nasal Polyps Are Removed: Medication, Surgery, and More - Healthline post-nasal drip a reduced sense of smell or taste facial pain headaches snoring sleep apnea Other reasons Sinus surgery may also be required due to other infections, ongoing blockages, abnormal. A multicenter comparison of maintenance and recovery with sevoflurane or isoflurane for adult ambulatory, 65. Then, theyll use the catheter to place a small balloon in your sinuses. 3. Our providers specialize in head and neck surgery and oncology; facial plastic and reconstructive surgery; comprehensive otolaryngology; laryngology; otology, neurotology and lateral skull base disorders; pediatric otolaryngology; rhinology, sinus and skull base surgery; surgical sleep; dentistry and oral and maxillofacial surgery; and allied hearing, speech and balance services. Br J Anaesth 2017;118:95960. Intubation Explained - WebMD Bilateral sphenopalatine ganglion blockade improves postoperative analgesia after, 152. Langeron O, Masso E, Huraux C, et al. Intubation has a risk of dental damage. Anesthesiology 2013;118:25170. An endotracheal tube is a flexible tube that is placed in the trachea (windpipe) through the mouth or nose. Take a break from strenuous activity for the next 10 days. The strategies to achieve these objectives are discussed below. 123. Endoscopic sinus surgery, sometimes called functional endoscopic sinus surgery (FESS) is a minimally invasive procedure to treat problems in the sinuses. Nasogastric (NG) Tube: Uses, Procedure, Risks, and More - Verywell Health Your healthcare provider may recommend you rinse your nose and sinuses with saline. Kesimci E, ztrk L, Bercin S, et al. Effects of three different types of anaesthesia on perioperative bleeding control in, 71. Factors affecting unanticipated hospital admission following otolaryngologic day surgery. Ther Clin Risk Manag 2010;6:11121. Cardiac and anti-HTN medications should usually be continued in the perioperative period. After surgery, you will spend a few hours in a recovery room to allow you to wake . Comparison of the antitussive effect of. Healthcare providers use general or local anesthesia when they do sinus surgery. Comparison of recovery profile after ambulatory, 64. Xu R, Lian Y, Li WX. tracheal intubation as the larynx is not directly stimulated; hence allowing the further advantage of haemodynamic . The additional advantage of IV esmolol may be related to its ability to potentiate opioid-induced analgesia, decrease the incidence of postoperative nausea and vomiting, and improve the overall patients recovery room profile118120,122131. Anesthesiology 2009;110:8917. The doctor uses a device called an endoscope, along with other tools, to access and treat the problem area through the nostrils. DeMaria S, Govindaraj S, Huang A, et al. Furthermore, the intraoperative use of IV fentanyl can either be completely avoided, or safely limited to a total dose 12mcg/kg for the majority of patients. Update on dexmedetomidine: use in nonintubated patients requiring sedation for surgical procedures. The incidence of PONV is reduced with TIVA and remifentanil use, as the emetogenic effect of inhalational anesthetics is avoided148. Sinus Surgery: Types, Procedure & Recovery - Cleveland Clinic Nekhendzy V, Ramaiah VK, Collins J, et al. 107. 75. Comparison of the optimal effect-site concentrations of, 137. Nausea and vomiting after office-based. Operative times, postanesthesia recovery times, and complications during sinonasal surgery using. Your provider may prescribe pain medication to help with the mild or moderate pain you may have for a week or so after your surgery. Tirelli G, Bigarini S, Russolo M, et al. Heres some general information: All surgeries come with potential complications and risks. Your healthcare provider will inject local anesthetic into the tissue lining your nose. Wawrzyniak K, Burduk PK, Cywinski JB, et al. The aim of our review is to look at the increasing body of literature highlighting the various . This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 146. Nasopharyngeal Airway - StatPearls - NCBI Bookshelf Schraag S, Pradelli L, Alsaleh AJO, et al. They inject a numbing solution into your nose. Anesthesiology 2000;92:122936. Blackwell KE, Ross DA, Kapur P, et al. 131. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Medicine (Baltimore) 2019;98:e17254. Lee B, Lee JR, Na S. Targeting smooth emergence: the effect site concentration of, 140. Several small prospective randomized trials attempted to further improve postoperative analgesia and patients recovery profile through the use of the regional nerve blocks, most commonly sphenopalatine ganglion block150157. For the most part, FESS has relatively few complications. Anesthesia for Ear, Nose and Throat Surgery | Anesthesiology The nonsteroidal anti-inflammatory medications (NSAIDs) and herbal supplements such as the 4 Gs (garlic, ginkgo biloba, ginseng, ginger) and certain vitamins (eg, vitamin E), may provoke microvascular bleeding and should ideally be discontinued at least 1 week before surgery when possible17,18. Nasogastric tubes pose very few risks when used correctly, but there is the possibility of side effects. Jacobi KE, Bohm BE, Rickauer AJ, et al. Prevention of this complication begins with recognition of a potentially difficult intubation and applying good practice rules. In a retrospective study of 136 FESS patients, Raikundalia et al164 identified concurrent septoplasty and younger patients age as the factors predisposing to increased postoperative opioid usage. 161. Bolus administration of esmolol for controlling the haemodynamic response to tracheal intubation: the Canadian Multicentre Trial. Anesthesia for Sinus Surgery. A prospective, randomized trial of 180 patients conducted under TIVA and CH demonstrated that the blood loss during FESS may be best predicted by the severity of preexisting sinus disease and duration of surgery94. 17. Some error has occurred while processing your request. Efficacy of tranexamic acid on operative bleeding in, 70. Youll have gauze under your nose to catch drainage that youll need to replace as the gauze becomes wet. Intubation is a procedure that can help save a life when someone can't breathe. Jaw surgery may be a corrective option if you have jaw problems that can't be resolved with orthodontics alone . 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, Functional Endoscopic Sinus Surgery (FESS). Endoscopic sinus surgery is a procedure used to remove blockages in the sinuses that cause pain, drainage, infections, impaired breathing or loss of smell. Smoking can make your sinus symptoms worse. The properly placed FLMA creates a reliable oropharyngeal seal, adequately protecting the lower airway from blood, secretions, irrigation fluid and surgical debris48,5557. Role of corticosteroids in. The IV placement on the patients side next to the surgeon (usually, on patients right), and the noninvasive blood pressure cuff on the opposite side may be recommended for FESS cases to avoid iatrogenic noninvasive blood pressureinduced tremor interference with precision surgery3. Oda Y, Nishikawa K, Hase I, et al. An FESS procedure may be necessary for people with recurrent sinusitis (sinus infection), sinus deformity, or abnormal growths in the sinuses for whom non-surgical treatments have failed. ORIF Surgery: Open Reduction Internal Fixation for Broken Bones Propofol versus sevoflurane: bleeding in, 80. Last reviewed by a Cleveland Clinic medical professional on 06/29/2022. Current data indicate that EC95 of the effect site concentration of remifentanil for blunting tracheal reflexes ranges between 1.5 and 2.9ng/mL (corresponding manual infusion rate 0.051.0mcg/kg/min)136145. Prediction of difficult mask ventilation. One of the primary benefits of balloon sinuplasty is that it's a safe procedure and complications are relatively rare. Provision of a clear and still surgical field and assuring smooth, nonstimulating emergence of anesthesia should constitute some of the top priorities for the anesthesiologist. Intubation is a standard procedure that involves passing a tube into a person's airway. Intubation Explained: Purpose, Risks, and Recovery - Verywell Health Shen PH, Weitzel EK, Lai JT, et al. If a deviated septum causes breathing problems, specialized instruments can straighten the septum and reduce the size of the turbinates (bony structures inside the sinuses). Tassler A, Kaye R. Preoperative assessment of risk factors. Multimodal PONV prophylaxis (eg, the addition of transdermal scopolamine patch) is warranted in high risk patients148,149. Simple sinus surgery may only require a small dose such as 4 mg IV dexamethasone; however, more extensive polyposis may require a dose up to 12 mg to further decrease postoperative edema. Nekhendzy V, Lemmens HJ, Vaughan WC, et al. Tests they may use include: Your healthcare provider will let you know what to do before your surgery. Svider PF, Nguyen B, Yuhan B, et al. Comparison of sodium nitroprusside- and esmolol-induced hypotension for, 79. A total of 1564 articles were identified and 1454 were analyzed after removing 200 duplicate papers. Heres an overview of the process: This is an alternative to FESS. Turbinate reduction is surgery to reduce the size of your turbinates. Endoscopic Dilatation Sinus Surgery (FEDS) Versus Functional Endoscopic Sinus Surgery (FESS) For Treatment of Chronic Rhinosinusitis: A Pilot Study. Coursin DB, Coursin DB, Maccioli GA. Dexmedetomidine. Albu S, Gocea A, Mitre I. Preoperative treatment with topical corticoids and bleeding during primary, 25. Why Do Some Patients Need To Be Intubated? Both the anesthesiologist and surgeon should be aware of this potential occurrence and the risks and benefits should be discussed. There are several types of sinus surgeries: In sinus surgery, a healthcare provider opens blocked sinus passages. Talk to a healthcare provider if youre weighing the risk and benefits of sinus surgery. 150. 147. For more information, please refer to our Privacy Policy. Intubation: What is it, types, procedure, side effects, and pictures Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis. So many surgeries are done with intubation still. The conventional interventions, such as elevating the patients head 1520 degrees67,68 (reverse Trendelenburg position should be avoided to prevent intraoperative fluid shifts), topical decongestion of the nasal mucosa, and the use of injectable vasoconstrictors by the surgeon play an important role in optimizing the view of the operative field. If you smoke, please try to stop smoking at least three weeks before your surgery. Editor - We read with interest the case report by Piepho et al(1) suggesting an algorithm for nasotracheal intubation. 124. This may go on for a few weeks while your sinuses heal. While infiltrative submucosal local anesthesia is used commonly by the surgeon intraoperatively, adequate analgesia may be difficult to attain secondary to preexisting mucosal inflammation, extensive polyposis, bleeding and other technical difficulties158. Anesthetic management for FESS presents some unique anesthesia-related considerations. Shukry M, Miller JA. 47. E-mail address: [emailprotected] (A. Saxena). Grzegorzek T, Kolebacz B, Stryjewska-Makuch G, et al. The forehead sensors for electroencephalogram-based assessment of the depth of anesthesia usually do not interfere with intraoperative use of stereotactic navigation system by the surgeon and can be particularly beneficial when TIVA is used. A Phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberoptic intubation. Caldwell Luc surgery involves going through your mouth to reach a sinus cavity and open a passage between that sinus and your nose. All rights reserved. Mioski J, Zieliska-Bliniewska H, Golusiski W, et al. *Corresponding author. Gollapudy S, Poetker DM, Sidhu J, et al. Does every surgery that require general anesthesia use intubation This suggests that factors such as adherence to meticulous surgical technique, and judicious use of epinephrine-containing local anesthetic solution to decongest nasal mucosa may be more important in reducing intraoperative bleeding than any single anesthesia-related intervention94. You may search for similar articles that contain these same keywords or you may Jaw surgery - Mayo Clinic Your healthcare provider may recommend FESS if you have chronic sinus inflammation or a chronic sinus infection that doesnt improve with medical treatments, such as antibiotics and medications to manage allergies. Patients with known or suspected OSA should be carefully screened for suitability for the same day ambulatory surgery, as they demonstrate the increased risk for perioperative complications38. Ask your healthcare provider to explain what kinds of complications you may have and what theyll do to help you if you do have complications from sinus surgery. Simple sinus surgery may only require a small dose such as 4mg IV dexamethasone; however, more extensive polyposis may require a dose up to 12mg to further decrease postoperative edema. Nasotracheal intubation is when the tube is put in through the nose. Every persons situation is different, but most healthcare providers recommend the following: Healthcare providers do functional endoscopic sinus surgery and balloon sinuplasty by inserting surgical tools into your nose. Depending on your daughter's age and which procedure is performed, she may or may not require intubation. Sinus surgery: Types, recovery, risks, and alternatives Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Desflurane versus sevoflurane for maintenance of outpatient, 67. Khosla AJ, Pernas FG, Maeso PA. Meta-analysis and literature review of techniques to achieve hemostasis in. The safety of perioperative esmolol: a systematic review and meta-analysis of randomized controlled trials. Functional endoscopic sinus surgery (FESS) is minimally invasive surgery for serious sinus conditions. Tramr M, Moore A, McQuay H. Propofol anaesthesia and postoperative nausea and vomiting: quantitative systematic review of randomized controlled studies. Ebert TJ, Hall JE, Barney JA, et al. The effect of the, 83. Doctors often perform it before surgery or in emergencies to give medicine or help a person breathe. Even small amounts of aspirin can increase how much you bleed during and after your surgery. Lee J, Kim Y, Park C, et al. They insert surgical tools alongside the endoscope to use the endoscope to remove bone, diseased tissue or polyps that may be blocking your sinuses. Most people have sinus surgery because they have severe sinus problems that medication hasnt helped. Nasogastric Tube Complications. Cook T, Woodall N, Frerk C. 4th National Audit Project of the Royal College of Anaesthetists. Turan A, You J, Egan C, et al. The adult patients presenting for FESS are diverse and could be either completely healthy (American Society of Anesthesiologists [ASA] physical status I) or have controlled systemic diseases of varying severity (ASA physical status IIIII). Comparison between dexmedetomidine and, 114. Healthcare providers perform this surgery to treat chronic sinusitis and to remove nasal polyps. Other people may need a few weeks or months before their symptoms go away. If the patients baseline functional capacity is moderate-to-excellent then additional cardiac testing should not be required. El-Shmaa NS, Ezz HAA, Younes A. Explore lung, breathing and allergy disorders, treatments, tests and prevention services provided by the Cleveland Clinic Respiratory Institute. . Apfelbaum JL, Hagberg CA, Caplan RA, et al. A comparison of effects of oral premedication with clonidine and metoprolol on intraoperative hemodynamics and surgical conditions during, 117. Another approach to extubation is ventilation through an extraglottic tracheal tube135. Incidence, predictors, and outcome of difficult mask ventilation combined with difficult laryngoscopy: a report from the multicenter perioperative outcomes group. Effect-site concentration of. Anesthesiology 2006;105:88591. 39. The effect of intraoperative use of esmolol and nicardipine on recovery after ambulatory surgery. Nearly 50% of patients with CRS and nasal polyposis develop comorbid asthma, which is thought to impact disease severity and deteriorate intraoperative conditions19,20. 60. Created for people with ongoing healthcare needs but benefits everyone. The success of endoscopic sinus surgery is greatly dependent upon properly administered anesthesia. The effectiveness of preemptive sphenopalatine ganglion block on postoperative pain and functional outcomes after, 151. They use an endoscope to increase the size of your maxillary sinus opening. There is some discomfort involved with the cleaning, so it is best to take a pain medication 45 minutes before your visit. Drummond GB. They connect with your nasal cavity. 20. 126. Proper anesthetic management, however, can indirectly decrease blood loss during FESS by improving the operating conditions and allowing for a more rapid surgery94. They may also use a small rotating burr to scrape out tissue. If inhalational anesthetic is chosen for maintenance, sevoflurane may be preferred, as it reduces the incidence of coughing and postoperative agitation compared with desflurane, and produces less somnolence and PONV compared with isoflurane6366. Choi SH, Min KT, Lee JR, et al. Propofol for maintenance of, 85. Intubation: When Needed, Benefits, and Risks - Healthline 4. The immediate recovery room period after FESS is usually uncomplicated. Using the endoscope, they gently enter your nose. Sinus Surgery for Treating Chronic Sinusitis - WebMD Dont take aspirin for at least seven days before your surgery. You may. 8. The possibility of difficult mask ventilation and difficult tracheal intubation shall always be considered in OSA patients3335. 162. Studies show between 80 % and 90% of people whove had this surgery feel it solved their sinus issues. Cho DY, Drover DR, Nekhendzy V, et al. Oral and maxillofacial surgery: To facilitate surgical access, patients may require nasal or submental orotracheal intubation. The essential anesthesia requirements for FESS include airway management considerations for facilitating surgical access, provision of a clear and still surgical field for precision surgery, assuring quick and nonstimulating emergence from anesthesia, and fast-tracking patients for discharge (Table 1). Comparison of the reinforced. The insertion procedure is brief lasting only a few minutes. Prevention of perioperative and. New masking guidelines are in effect starting April 24. FESS is characterized by low postoperative pain scores146, and remifentanil represents a nearly ideal intraoperative opioid due to its context-insensitive half-life, superior potency and titratability, and demonstrated improvement of respiratory and general patient recovery after outpatient surgery (Nekhendzy and colleagues)4. Nasal saline mist can be used every three to four hours after surgery to keep your nose moist and humidified. If FLMA is chosen, meticulous attention must be directed to the confirmation tests for its placement, to assure adequate ventilation and airway protection58. the use of FLMA may offer significant advantages, including decreased incidence of the upper airway trauma and adverse respiratory events, facilitation of maintenance of anesthesia and quality of surgical field, and smoother and faster emergence from anesthesia4,4754. Most people have sinus surgery because they have severe sinus problems that medication hasnt helped. Search for Similar Articles Yu SK, Tait G, Karkouti K, et al. Evaluation of the patients cardiac status should follow the American College of Cardiology (ACC) and American Heart Association (AHA) guidelines on perioperative evaluation and care for noncardiac surgery13. 130. Effect of infraorbital nerve block under, 154. 53. Functional Endoscopic Sinus Surgery | AAFP 105. 110. Surgical conditions during FESS; comparison of dexmedetomidine and, 116. Most patients feel well enough to go home a few hours after the surgery. Mehta U, Huber TC, Sindwani R. Patient expectations and recovery following. 160. 102. Nasogastric Tubes: How Do They Impact Your Health? - WebMD Focused patient assessment and preparation shall be aimed at optimizing intraoperative surgical exposure and minimizing factors that may promote bleeding in the perioperative period. If you had local anesthesia, youll be able to go home right away. Oral O2 administration makes capnography monitoring unreliable, and placement of the precordial stethoscope over the patients trachea to monitor breath sounds may be recommended. Otolaryngol Clin North Am 2016;49:51729. The efficacy of Labetalol versus Nitroglycerin for induction of, 121. Complication rates after. Perioperative use of inhaled bronchodilators is indicated in these patients16, and intraoperative use of NSAIDs including IV ketorolac, should be avoided21. Studies show between 80 % and 90% of people who have FESS for chronic sinusitis feel the surgery cured their problem. The use of FLMA in lieu of ETT will enable smooth patient awakening and allow for safe reduction of the level of anesthesia near the end of the surgery4,58. Ann Otol Rhinol Laryngol 2018;127:297305. Local and regional anesthesia (eg, sphenopalatine ganglion block) facilitates MAC cases, and its use is widespread to supplement general anesthesia, which is performed far more frequently. Bairy L, Vanderstichelen M, Jamart J, et al. In small prospective trials, the use of both oral and IV clonidine effectively improved the surgical field for different anesthetic techniques during FESS, compared favorably with IV remifentanil, but results in undesired carry-over patient sedation95101. Functional Endoscopic Sinus Surgery (FESS) - Cleveland Clinic Anaesthetic Concerns for Functional Endoscopic Sinus Surgery Suzuki S, Yasunaga H, Matsui H, et al.